The Lexus RX 350 and the Audi Q5 are two great vehicles. Although the Audi Q5 does come out on top, both feature good engines and are comfortable enough for long road trips or commuting. Both vehicles also have different trim levels to accommodate those who want the basics or everything under the sun.


The Lexus RX 350 features a 3.5-liter V6 engine that makes 295 horsepower and 268 pound-feet of torque. The Audi Q5’s 2.0-liter turbocharged four-cylinder engine makes 248 horsepower and 273 pound-feet of torque and has a top track speed of 130 mph while the Lexus’ top track speed is 124 mph. While the Q5 has less horsepower, it produces more torque, which means the Q5 will get off the line faster than the RX 350 because it has more bottom-end power.

The front-wheel drive RX 350 features an eight-speed electronically controlled transmission while the Q5 features a seven-speed S-tronic dual clutch automatic transmission and Quattro all-wheel drive with Ultra technology. The RX 350 gets 20 mpg in the city, 27 mpg on the highway and 23 mpg combined while the Q5 beats it out with 22 mpg in the city, 27 mpg on the highway and 24 mpg combined.

Although the Q5 has less horsepower, it has more torque, making it a more powerful engine, and it beats the RX 350 for gas mileage. Our pick is the Audi Q5 for performance.

2021 Audi Q5 Display
Both vehicles feature a 12.3-inch display with navigation, however, the Q5’s navigation screen is located in the gauge cluster, making it easier to glance at. The RX 350’s is mounted to the right of the driver and navigation is optional. On the Audi, a second touchscreen provides access to Apple CarPlay, Android Auto and a host of other features. Both vehicles feature voice control and Bluetooth. Our pick is the Audi Q5 because of the dual displays and great navigation graphics.
2021 Audi Q5 Interior
Both vehicles feature a panoramic sunroof/moon roof and ambient lighting. The Audi has much more cargo space when all passenger seats are being used with 25.1 cubic feet to the Lexus' 18.4 cubic feet. The Audi features leather upholstery, while the Lexus features leatherette upholstery. The standard stereo system for the Audi has ten speakers while the Lexus has nine speakers. The Audi comes standard with tri-zone automatic climate control while the Lexus has standard dual-zone automatic climate control with the third zone as optional equipment. Overall, the Audi has the better interior of the two vehicles with more comfortable seating.

Safety Features

Though the Lexus has standard lane departure warning and lane keeping assist, the Audi Q5 received better NHTSA crash test scores. The Audi received five stars overall while the Lexus received an overall rating of four stars. Both vehicles received five stars for side crash protection, but the Q5 received five stars for rollover crashes to the four-star rating on the Lexus.

Both vehicles have front and rear head and side airbags, four-wheel ABS disc brakes, brake assist, electronic stability control, daytime running lights, traction control, auto-leveling headlights and blind spot monitoring. Our pick is the Audi Q5 because of the better safety ratings.